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FIGURE 5. Wnt/β-catenin signaling is not required for liver specification in Gata4-AC and AC/AE. (A) Gata4 and dkk-1 mRNA co-injection in animal pole explants causes a well-described increase in cardiac marker levels but has no effect on nr1h5. (B) qPCR analysis confirms these findings and extends them by showing no significant effect on hhex and foxa2. (C) dkk-1 expression in AC/AE (injected in AC) likewise has no effect on nr1h5. RT-PCR analyses were performed on st. 34 explants and sibling embryo controls. Image published in: Haworth K et al. (2019) Copyright © 2019 Haworth, Samuel, Black, Kirilenko and Latinkic. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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