XB-IMG-175363
Xenbase Image ID: 175363
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Figure S3. Schematic of the UDP-GlcNAc salvage pathway (A) Free GlcNAc is released from glycosylated proteins in lysosomes and transported to the cytosol. (B) In a series of reactions, the salvage pathway converts the free pool of cytosolic GlcNAc into UDP-GlcNAc. (C) UDP-GlcNAc is used in a reaction that covalently attaches GlcNAc to dolichol phosphate in the cytosol. The product, GlcNAc-PP-dolichol, is subsequently flipped into the ER lumen to initiate the process of N-glycosylation. GlcNAc, N-acetyl-D-glucosamine; GlcNAc-1-P, N-acetyl-D-glucosamine-1-Phosphate; GlcNAc-6-P, N-acetyl-D-glucosamine-6-phosphate; UDP-GlcNAc, Uridine diphosphate- N-acetyl-D-glucosamine; Nagk, N-acetylglucosamine kinase; Pgm3, N-acetylglucosamine-phosphate mutase; Uap1, UDP-N-acetylglucosamine pyrophosphorylase 1; Dpagt1, Dolichyl-phosphate N-acetylglucosamine phosphotransferase 1.
Image published in: Neitzel LR et al. (2019) Copyright © 2019. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View |