XB-IMG-175424
Xenbase Image ID: 175424
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Figure 4. Loss of Prdm12 Blocks the Initiation of the Expression ofNtrk1and Alters the Gene Expression Program of Early Nociceptor Development (A) Volcano plot showing the fold change and significance of selected mis-regulated genes in DRG and spinal cord between E11.5 WT versusPrdm12KOembryos (four samples per genotype). Downregulated genes are highlighted in red, and upregulated genes are highlighted in blue.(B–D) ISH analysis of the expression of the indicated genes that are down-regulated (B), upregulated (C), or unchanged (D) in the DRG of E11.5 KO embryos compared to WT. Arrowheads in (C) point to ectopic Krox20 and Mpz expression. Dashed lines delineate the DRG. Scale bars, 50mm. Image published in: Desiderio S et al. (2019) Copyright © 2019. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |