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Figure 5. Late Ablation of Prdm12 in Developing Sensory Neurons Decreases the Expression of Ntrk1and Other Nociceptive Markers and Results in a Loss of NociceptorsTransverse sections of lumbar DRG of Prdm12 cKO and control embryos immunostained or in situ hybridized with the indicated markers. (A) Proportion of Prdm12+neurons among Islet1+neurons in DRG of control andPrdm12cKO embryos from E13.5 to E16.5. Islet1+neurons progressively no longer express Prdm12 (mean ± SD), and their number is gradually reduced (individual values of the biological replicates are indicated with dots). Image published in: Desiderio S et al. (2019) Copyright © 2019. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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