Xenbase Image ID: 175535

Figure 4. T3 affect a similar network of pathways in both species, despite regulating different sets of genes. Networks of KEGG pathways affected in Axolotl (A) and X. tropicalis (B). The reconstructed network for Axolotl is composed of 3,305 nodes and 12,776 edges, with a densely connected component (2,274 nodes and 12,554 edges), some weakly connected genes (273 genes and 222 edges) and a set of singletons (758 nodes). The X. tropicalis network is composed of 3,561 nodes and 16,237 edges, with a highly interconnected component (2,443 nodes and 15,950 edges), some weakly connected genes (318 genes and 287 edges) and a set of singletons (800 nodes). Nodes correspond to gene products, linked together by the functional interactions described in the pathways (edges). Individual node size is proportional to the number of nodes connected to it. Large nodes thus correspond to hubs between KEGG pathways. Red: nodes in common to both networks. Blue: nodes only found in one (or the other) network. Layout computed with the prefuse force directed algorithm. (C) Overlap between the node (gene product) content of the two networks. (D) Cumulative distribution of node connectivity (degree). In both species, T3 do not target (or avoid) specific network components. Image published in: Kerdivel G et al. (2019) Copyright © 2019. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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