Xenbase Image ID: 175538

Figure 7. Axolotl tailfin transcriptional responses to T3 at pre-HTP and paedomorph stages. (A) Overlap between T3-responsive gene sets at pre-HTP and 6 months old paedomorph stages, measured by RNA-Seq. (B) Heatmap of differentially expressed genes at pre-HTP and paedomorph stages. (C) Expression fold changes at pre-HTP vs. old paedomorphs. (D) Gene ontology analysis. Top: Number of genes for each GO term (not shown), at both stages. Red: Number (Nbr) of terms found at pre-HTP. Blue: Number of terms found in paedomorph. Bottom: ratio of the number of terms found at each stage for each GO term (in the same order as the top panel). Positive and negative values correspond to terms mostly found at pre-HTP or paedomorph gene set, respectively. (E) RT-qPCR normalized gene expression changes (log2 Fold Change) after T3 treatment. Tailfin transcriptional response to T3 differs between class 3 larvae and 6 months old paedomorphs. Statistical significance (Mann-Whitney test) with *p ≤ 0.05. Image published in: Kerdivel G et al. (2019) Copyright © 2019. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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