XB-IMG-175708
Xenbase Image ID: 175708
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Fi.10. Model. a Diagram summarising the expression of Sema3A (red), Sema3F (blue), Sdf1 (grey, stripped), and the distribution of Fibronectin (green fibres) on a transversal section at the onset of NC cell migration (NC cells are in green). b Diagram of the proposed signalling events taking place. Sdf1 activates Rac1 whereas Sema3A inhibits Rac1. Medio-dorsally, Fibronectin and Sdf1 are lacking. Thus, the effect of Sema3A on Rac1 dominate and NC cells cannot adhere to the matrix. Ventro-medially, all players are present. Sdf1 counterbalances Sema3A, NC cells can adhere to Fibronectin. No, notochord; Plx/Nrp, plexins/neuropilins
Image published in: Bajanca F et al. (2019) © The Author(s) 2019. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |