Xenbase Image ID: 176012

Figure S5. Validation of Computational Model for Zygotic Genome Activation. Related to Figure 5. (K-N). (K-N) Fitting experimental data and overlay with predicted models. Split out of plots from Figure 4K. (K) Experimental data showing fraction of activated cells as a function of position along AV axis. Data from five embryos at indicated developmental stage (log2 cell number); equivalent to early-mid ZGA. Fitting to individual embryos. Thick gray line indicates average fit to all 5 embryos; confidence interval shown in light gray. (L) Timer model prediction of fraction activated cells as a function of position along AV axis by timer (red line), compared to experimental data (gray line and confidence interval). (M) Cell sizer model prediction of fraction activated cells as a function of position along AV axis by timer (blue line), com- pared to experimental data (gray line and confidence interval). (N) Cell cycle counter model prediction of fraction activated cells as a function of position along AV axis by timer (green line), compared to experimental data (gray line and confidence interval). Image published in: Chen H et al. (2019) Copyright © 2019. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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