Xenbase Image ID: 176911

Fig. S22 Kcp augments BMP signaling. (A) Control embryos; mock injected. (B) Embryos injected with 500 pg Kcp mRNA. Embryos display protrusions (red arrows). (C) Embryos injected with 500 pg Bmp2 mRNA. Embryos displaying partial double axis (red arrows). (D) Embryos injected with 500 pg Kcp mRNA + 500 pg Bmp2 mRNA. Embryos displaying partial double axis, posterior truncations, edema. (E) Graph of the classes of phenotypic abnormalities in wild-type embryos verses those injected with Kcp alone, BMP2 alone, or BMP2 + Kcp. Results from 2 independent biological replicates with total number of embryos scored under each heading. See S17 Table for numerical data underlying figure. BMP, bone morphogenetic protein; Kcp, Kielin/chordin-like protein. Image published in: Federspiel JD et al. (2019) © 2019 Federspiel et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Experiment + Assay Source Phenotypes and Disease Xla Wt + kcp + NF37/38 (whole-mount microscopy) Fig S22 B Anatomical Phenotype abnormal axis specification abnormal head morphology Xla Wt + bmp2 + NF37/38 (whole-mount microscopy) Fig S22 C Anatomical Phenotype abnormal axis specification Xla Wt + kcp + bmp2 + NF37/38 (whole-mount microscopy) Fig. S22 D Anatomical Phenotype abnormal axis specification abnormal head morphology decreased length of trunk edematous embryo obsolete duplicated anatomical axis Larger Image Printer Friendly View

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