Xenbase Image ID: 177751

Figure 7. The Lef1 targets of the caveolin family are required for Wnt5a induced receptor complex internalization. (a) Lef1 regulates the expression of the caveolar core components caveolin1, caveolin3 and cavin1. (b) Wnt5a induces rapid clustering of non-canonical receptor complexes and subsequently their internalization via clathrin and caveolin dependend mechanisms, (c) Apical internalization of receptor clusters results in a symmetry break of polarized cells with membrane bound receptor clusters at the basal membrane. Image published in: Puzik K et al. (2019) © The Author(s) 2019. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page