Xenbase Image ID: 180085

Figure 3. Organ situs determination in conjoined twins. Experimentally created conjoined Xenopus embryos harbor a fused LRO in which the left margin of the right twin’s LRO is fused to the right margin of the left one. Cilia-generated flow across the fused LRO represses dand5 and induces asymmetric LRO Nodal signaling only in the left twin, while flow is insufficient to de-repress nodal1 in the fused central domain. As a result, the right twin lacks a biased asymmetric LRO signal and organ asymmetry develops in a random fashion. Image published in: Blum M and Ott T (2019) Copyright © 2019. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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