Xenbase Image ID: 1830

Fig. 1. Xisl-1 protein domains and temporal expression pattern. (A) The Xisl-1 ORF codes for a 354 amino acid (aa) protein, which contains two LIM protein–protein interaction domains and a homeobox DNA binding domain as indicated. A comparison of the Islet-1 amino acid sequence between different species demonstrates a high evolutionary conservation. The Isl-1 protein of frog, fish, chick, mouse and human show a 96–98% overall homology. The overall homology to the Drosophila Islet-1 protein is only 55%, however the LIM domains and the homeodomain are more conserved with 69–89% homology. The functional domains of vertebrate Isl-1 are 95% to 100% homologous. (B) RT-PCR analysis of the temporal expression pattern of Xisl-1. Xisl-1 transcripts are present maternally at low levels. During late gastrula stages (st.12.5) Xisl-1 is significantly upregulated and continues to be expressed at similar levels at least until tailbud stages. Image published in: Brade T et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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