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Fig. 8. Effects of single PG1 knockdowns on Hox genes. Embryos injected on the left-hand side (lhs) with the triple PG1 MO combination had reduced Hoxb2 (A: 93%, n=28), Hoxa3 (E: 100%, n=14) and Hoxd4 (I: 79%, n=14). The Hoxa1 MO weakly downregulated Hoxb2 (B: 80%, n=10) and reduced Hoxa3 (F: 54%, n=11), but not Hoxd4 (J: 100%, n=20). The Hoxb1 MO had no effect on any of these genes (C: Hoxb2, 100%, n=10; G: Hoxa3, 100% n=9; K: Hoxd4, 100%, n=18). Hoxd1 MO reduced Hoxd4 expression (L: 100%, n=16), weakly reduced Hoxb2 (D: 43%, n=14), but did not affect Hoxa3 (H: 100%, n=10). Image published in: McNulty CL et al. (2005) Copyright © 2005. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue hoxb2.S X. laevis Throughout NF stage 22 pharyngeal arch hindbrain posterior branchial crest anterior neural tube hoxa3.S hox1e, hoxa-3, hoxa3a X. laevis Throughout NF stage 22 hindbrain cranial neural crest spinal cord anterior branchial crest hoxd4.L LOC108703007 X. laevis Throughout NF stage 22 hindbrain neural tube spinal cord Image source: Published Larger Image Printer Friendly View

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