Xenbase Image ID: 23201

Fig. 2. Effects of RA signaling overexpression on eye DV polarity. (A) Low RA doses (0.1 μM) expand Pax2, Vax1b and Raldh3 expression domains, but do not significantly affect Vax2- and ET-positive regions in stage 33 Xenopus embryos. Pax2-hybridized embryos are also shown in frontal view (right column). (B) High RA doses (10 μM) upregulate Vax2 in the DR and repress Vent2, Pax2, Vax1b and Raldh3, but do not change Pax6 expression. (C) Schematic representation of the results shown in A and B. Low RA levels enlarge the OS. High RA levels ventralize the retina and repress OS formation. Image published in: Lupo G et al. (2005) Copyright © 2005. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue vax1 vax, vax1-a, vax1-b, vax1b, vax1b-a, xvax1, xvax1b Xenopus Throughout NF stage 33 and 34 optic stalk retina ventral pax6 an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 Xenopus Throughout NF stage 33 and 34 retina diencephalon pax2 LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 Xenopus Throughout NF stage 33 and 34 optic stalk retina ventral vax2 dres93, vax2-a, vax2-b, vax3, xvax2 Xenopus Throughout NF stage 33 and 34 retina ventral ventx2.2 vent-2, vent2, Xom, xvent-2, xvent2 Xenopus Throughout NF stage 33 and 34 retina dorsal aldh1a3 raldh3 Xenopus Throughout NF stage 33 and 34 optic stalk retina ventral Image source: Published Larger Image Printer Friendly View

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