Xenbase Image ID: 23204

Fig. 5. Raldh3 overexpression in the presence of ATR reproduces the effects of RA treatments on eye DV polarity. (A) Embryos were bilaterally injected with a total of 1 ng Raldh3 mRNA and treated with 0.5 μM ATR from stage 12.5/13, followed by molecular marker analysis at stage 33. The combination of Raldh3 and ATR expands Pax2 expression, while ATR alone has only a weak effect. A comparable expansion of Pax2 is obtained by a dose of 2 μM ATR in the absence of exogenous Raldh3. (B) The combination of 4 ng Raldh3 mRNA and 2.5 μM ATR can upregulate Vax2 in the DR, while ATR alone has only a weak effect. Strong Vax2 upregulation is also caused by a dose of 10 μM ATR in the absence of exogenous Raldh3, as shown in both lateral (upper row) and anterior view (lower row). Image published in: Lupo G et al. (2005) Copyright © 2005. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue pax2 LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 Xenopus Throughout NF stage 33 and 34 optic stalk retina ventral otic vesicle otic placode hindbrain vax2 dres93, vax2-a, vax2-b, vax3, xvax2 Xenopus Throughout NF stage 33 and 34 optic stalk retina ventral diencephalon Image source: Published Larger Image Printer Friendly View

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