Xenbase Image ID: 23209

Fig. 10. Loss-of-function effects of RA, Hh and FGFR signaling pathways on eye DV polarity. Embryos were treated from stage 10.5 with 10 μM AGN194310 (AGN), 100 μM cyclopamine (CPM) and 25 μM SU5402 (SU) in different combinations, and analyzed for molecular marker expression at stage 30/31. (A) Effects of the single inhibition of any of the RA, Hh and FGFR signaling pathways, when compared with mock-treated embryos. (B) Effects of double and triple inhibition of RA, Hh and FGFR pathways. (C) Schematic representation of the results shown in A and B. Strong eye dorsalization is caused by triple inhibition of RA, Hh and FGFR signaling, while double inhibitions produce weaker effects. Image published in: Lupo G et al. (2005) Copyright © 2005. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue vax2 dres93, vax2-a, vax2-b, vax3, xvax2 Xenopus Sometime during NF stage 29 and 30 to NF stage 31 optic stalk retina ventral pax2 LOC108697493, pax-2, pax2-a, pax2-b, XPax-2, XPax2 Xenopus Sometime during NF stage 29 and 30 to NF stage 31 optic stalk retina ventral hindbrain epibranchial placode Image source: Published Larger Image Printer Friendly View

Return to previous page