Xenbase Image ID: 23562

Figure 6. The Dorsalizing Effects of Wnt Inhibition Are Rescued by SGM(A–C) Dkk1 (n = 28) and Chordin (n = 45) protein (R&D) injections into the blastula cavity (60 nl of 2.5 μM and 0.5 μM, respectively) present considerable phenotypical similarities.(D) Proposed molecular pathway.(E–H) Dkk1 mRNA suppresses the antineural phenotype of BMP4 overexpression (n for each sample was 18, 13, 23, and 18, respectively).(I–P) Wnt8 MO causes dorsalization, which is blocked by GSK3-resistant SGM, but not by SWT mRNA (n for each sample was 22, 17, 23, and 26, respectively).(Q–T) The expansion of the neural plate by Dkk1 mRNA is rescued by GSK3-resistant SGM, but not SWT mRNA (n = 30, 22, 21, and 27, respectively). Image published in: Fuentealba LC et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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