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Fig. 6. Xmxi1 inhibits genes required for cell cycle withdrawal but does not influence neurogenic and early proneural genes. (A–G) Whole-mount in situ hybridization of stage 14 embryos injected with 500 pg of MT-Xmxi1. Antisense probes used are indicated in the lower left hand corner. The injected side is always on the right, and all embryos are shown as dorsal views, anterior down. (H) Transversal section of G. (I) Xmxi1 blocks induction of late, but not early X-ngnr-1-induced target genes in animal caps. Real-time RT-PCR analysis of animal cap explants isolated from embryos injected with X-ngnr-1 (25 pg) alone or together with MT-Xmxi1 (500 pg). Expression levels were normalized to ODC and compared to the induction capacity of X-ngnr-1 injected animal caps, which were set to 10. Image published in: Klisch TJ et al. (2006) Copyright © 2006. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue neurog2.L atoh4, neurog2-a, neurog2-b, neurogenin 2, neurogenin-2, neurogenin-related-1, neurogenin2, ngn-2, ngn2, ngnr, ngnr 1a, Ngnr-1, Ngnr1, X-ngnr-1, xngn2, Xngnr-1, XNgnr1 X. laevis Throughout NF stage 14 neural plate chordal neural plate neuron trigeminal placode lateral dll1.L delta-1, Delta-1, delta1, x-delta, X-delta-1, Xdelta-1, Xdelta1, XDelta1 X. laevis Throughout NF stage 14 chordal neural plate trigeminal placode hes5.6.L X. laevis Throughout NF stage 14 chordal neural plate trigeminal placode anterior myt1.S X-MyT1, xmyt1, XMyTI X. laevis Throughout NF stage 14 chordal neural plate lateral trigeminal placode neurod1.L neurod, neuroD, neurod1-a, neurod1-b, XNeuroD X. laevis Throughout NF stage 14 chordal neural plate lateral neuron trigeminal placode pak3.L bpak, cdkn1a, mrx30, mrx47, ophn3, pak3beta, XPak3 X. laevis Throughout NF stage 14 chordal neural plate lateral neuron cdkn1a.L cip1, p16Xic2, p21 X. laevis Throughout NF stage 14 neuroectoderm neural plate axial mesoderm paraxial mesoderm myotome Image source: Published Larger Image Printer Friendly View

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