Xenbase Image ID: 23792

Fig. 3. XHRT1, esr9, esr10, Xhairy1 and Xhairy2b are responsive to Notch signaling in the pronephric mesoderm (arrowheads). Whole-mount in situ analysis of stage 23-30 embryos injected with hGR/Su(H)/Ank or Su(H)DBM mRNA. The inducible construct was activated at stage 18. (A, parts a-t) Control and injected sides of embryos, anterior right. Note the posterior expansion of the expression of the different bHLH-O genes on the injected side of hGR/Su(H)/Ank-injected embryos (arrowheads). Note the inhibition of their expression in Su(H)DBM-injected embryos (arrowheads). Except in d,f,h and j, the injected side is revealed by β-gal staining (red). (B, parts a-e) Transversal sections of the embryos shown in b,d,f,h,j at the level indicated. Note that the strongest esr9, esr10 and XHRT1 ectopic staining is detected in the lateral part of the intermediate mesoderm, while Xhairy1 and Xhairy2b expression is found in both layers (arrowheads). Xhairy2b is also strongly activated in the ectoderm (arrow). (B, part f) Transversal sections in stage 23 embryos in the posterior portion of the pronephros showing that XHRT1 ectopic expression in response to activation of Notch is already detected at that stage in both layers. (B, part g) Transversal section in the posterior portion of the pronephros of stage 23 embryos stained with xWT1. Ectopic staining of xWT1 is restricted to the medial layer. Image published in: Taelman V et al. (2006) Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue hey1 bc8, chf2, herp2, hesr1, hrt-1, hrt1, oaf1, XHRT1 Xenopus Sometime during NF stage 23 to NF stage 29 and 30 pronephric kidney hes5.7 esr9, hes9, hes9.1-a, hes9.1-b Xenopus Sometime during NF stage 23 to NF stage 29 and 30 pronephric kidney hes5.5 esr10 Xenopus Sometime during NF stage 23 to NF stage 29 and 30 pronephric kidney hes4 H2, hairy2, hairy2a, hairy2b, hes4-a, hes4-b, hes4a, hes4b, Xhairy2, XHairy2a, Xhairy2b Xenopus Sometime during NF stage 23 to NF stage 29 and 30 pronephric kidney ectoderm hes1 hairy1, hes-1, hes1-a, hes1-b, Xhairy1 Xenopus Sometime during NF stage 23 to NF stage 29 and 30 pronephric kidney Image source: Published Larger Image Printer Friendly View

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