Xenbase Image ID: 23836

Fig. 2. Expression of XOtx5b and XOtx2 in retinal sections. Section in situ hybridisation of XOtx2 (A-E) and XOtx5b (F-J) in the Xenopus retina at stages 25/26 (A,F), 28 (B,G), 33 (C,H), 37 (D,I) and 41 (E,J). (A,F) XOtx2 (A) is expressed throughout the presumptive retinal pigment epithelium and retina while XOtx5b (F) expression is only in the central retina. (B,G) As retinal invagination progresses, expression of both XOtx2 (B) and XOtx5b (G) appear in the central retina. (C,H) Expression of XOtx2 (C) and XOtx5b (H) is identical. Transcripts from either of these genes are found throughout the developing retina except in the peripheral dorsal and ventral regions. (D,I) The central retinal expression of these two transcripts is reduced to particular layers. XOtx2 (D) is expressed in the outer edge of the inner nuclear layer (INL). XOtx5b (I) is also found in the outer edge of the INL and also in the outer nuclear layer (ONL). The peripheral retina still expresses these transcripts in the ganglion cell layer. (E,J) When the retina is mature, XOtx5b (J) is found in both the photoreceptor layer and the outer cells of the INL. Like XOtx2 (E), it is also found in the edge of the CMZ. XOtx2 is also expressed in cells at the outer edge of the INL. Bars: 20 μm; dashed lines indicate the extent of developing neural retina in A-D,F-I. Image published in: Viczian AS et al. (2003) Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue crx crx-a, crx-b, otx5, otx5b, Xotx5, Xotx5b Xenopus Sometime during NF stage 25 to NF stage 26 retina otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Sometime during NF stage 25 to NF stage 26 retinal pigmented epithelium retina otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Throughout NF stage 28 to NF stage 33 and 34 retina crx crx-a, crx-b, otx5, otx5b, Xotx5, Xotx5b Xenopus Throughout NF stage 28 to NF stage 33 and 34 retina otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Throughout NF stage 37 and 38 retinal inner nuclear layer retinal ganglion cell layer crx crx-a, crx-b, otx5, otx5b, Xotx5, Xotx5b Xenopus Throughout NF stage 37 and 38 retinal outer nuclear layer retinal inner nuclear layer otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Throughout NF stage 41 photoreceptor layer retinal inner nuclear layer otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Throughout NF stage 41 ciliary marginal zone retinal inner nuclear layer crx crx-a, crx-b, otx5, otx5b, Xotx5, Xotx5b Xenopus Throughout NF stage 41 photoreceptor layer retinal inner nuclear layer ciliary marginal zone Image source: Published Larger Image Printer Friendly View

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