Xenbase Image ID: 23952

Figure 7. Triple Knockdown of ONT1, ADMP, and BMP2 Results in a Dramatic Shift toward Dorsalization(A and B) BMP2 expression (dorsal view) was strongly expanded at stage 11.5 in an embryo coinjected with ONT1-MO (12.5 ng) and ADMP-MO (3 ng).(C–H) Triple knockdown of ONT1, ADMP, and BMP2 caused a dramatic dorsalization of the embryo. Embryos were given microinjections of ADMP-MO (3 ng), BMP2-MO (8 ng), and ONT1-MO (8 ng). Whole-mount in situ hybridization of Gsc ([C, E, and G]; anterior view) and Shh ([D, F, and H]; dorsal view) expression at stage 13. Image published in: Inomata H et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue bmp2.S BMP-2, bmp2-a, bmp2-b, xBMP-2, xbmp2 X. laevis Throughout NF stage 11 anterior endomesoderm upper blastopore lip Image source: Published Larger Image Printer Friendly View

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