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Fig. 5. Loss of DM-GRASP affects marker gene expression in the FHF but not the SHF. (A) DM-GRASP MO was unilaterally injected at the 8-cell stage and expression of cardiac marker genes was monitored at stage 20. No changes for Tbx20, Isl-1 and Nkx2.5 could be detected. Anterior views of whole embryos are given. (B) DM-GRASP MO was unilaterally injected at the 8-cell stage and expression of cardiac marker genes as indicated was monitored at stage 28. Loss of DM-GRASP resulted in down-regulation of some marker genes of the FHF (arrows) but not SHF such as Isl-1 or BMP-4. Ventral views of embryos are given. (C) Quantitative presentation of observed phenotype in panel B. Error bars are standard errors of the means. N = number of examined embryos, n = number of independent experiments. Image published in: Gessert S et al. (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue bmp4.L bmp2b, bmp2b1, bmp-4, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme X. laevis Throughout NF stage 28 cardiac mesoderm heart heart primordium tbx20.L XTBX20 X. laevis Throughout NF stage 28 cement gland cardiac mesoderm heart heart primordium nkx2-5.S AR2, csx, nkx-2.5, Nkx-2.5, nkx2.5, nkx2-5-a, nkx2-5-b, tinman, XNkx-2.5, XNkx2-5 X. laevis Throughout NF stage 28 cardiac mesoderm heart heart primordium tnni3.L cardiac tropin T, cardiac troponin I, cTnI, ctnIc, cTNT, c-troponin, TIc, TnIc, tnnic, troponin-ic, XcTnI, XTnIc X. laevis Throughout NF stage 28 cardiac mesoderm heart heart primordium wnt11.S wnt11a, Wnt11-R, Wnt11r, WNT11-related X. laevis Throughout NF stage 28 cement gland cardiac mesoderm branchial arch heart cranial neural crest hyoid crest mandibular crest branchial crest heart primordium isl1.S islet-1, islet1, Xisl-1, Xislet-1 X. laevis Throughout NF stage 28 cardiac mesoderm heart heart primordium actc1.L actc, actna1, cardiac actin, cardiac alpha actin, muscle actin X. laevis Throughout NF stage 28 cardiac mesoderm heart heart primordium Image source: Published Larger Image Printer Friendly View

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