Xenbase Image ID: 24557

Fig. 7. Snail lies upstream of Slug in the cascade leading to neural crest development. One blastomere of a two-cell stage embryo was co-injected with the different dominant-negative constructs and the wild type, treated with dexamethasone at stage 12.5, fixed at stage 19 and the expression of the neural crest markers analysed. The injected side is indicated by an arrowhead. (A,B) XsnailZnFGR rescued by XslugGR: the effect of the zinc fingers dominant-negative Snail construct was rescued by co-expression of Slug. Note the normal expression of neural crest markers in the injected side. (C,D) Effect of injecting XslugNGR dominant-negative construct. Note the inhibition in the expression of the markers in the injected side. (E,F) Co-injection of XslugNGR and XsnailGR: note that the effect of the dominant-negative Slug construct can not be rescued by co-expression of Snail. Image published in: Aybar MJ et al. (2003) Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue snai2 slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 Xenopus Throughout NF stage 19 neural crest neuroectoderm foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 19 neural crest neuroectoderm Image source: Published Larger Image Printer Friendly View

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