Xenbase Image ID: 24577

Fig. 3. Phenotypes resulting from Coco overexpression in Xenopus embryos. Analysis of injected embryos at gastrula (A-D), neurula (H) and early tadpole stages (E-G,I-N). In A-D and H-N, the top panels are uninjected embryos, the lower panels are embryos injected with 1 ng Coco vegetally in 1 cell at the 2-cell stage (A-D) or ventrally in one cell at the 4-cell stage (G-N). (A) Xbra/brachyury (a marker of mesoderm); (B) Fgf8, also a mesoderm marker, (C) Otx2, (the organizer and anterior ectoderm); (D) gsc (organizer); (H) rx, (forebrain); (I) Emx1 (dorsal telencephalon); (J) Otx2, forebrain and midbrain; (K) En2 (midbrain/hindbrain boundary); (L) Hoxb9 (spinal cord); (M) Nkx2.5 (heart) (N) 12-101 Ab (muscle). (E-G) Phenotypes resulting from (E) no injection (control embryo); (F) dorsal animal injection at the 2-cell stage; (G) injection in one ventral vegetal cell at the 4-cell stage. *indicates the extra head structures. A,B,D are vegetal views; C, lateral with animal pole to the top; E-G,I-K, lateral views; H,L,N dorsal views; M, ventral view. In E-N, anterior is to the right. Image published in: Bell E et al. (2003) Copyright © 2003. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 10.5 mesoderm marginal zone fgf8.L AIGF, FGF-8, fgf-8b, fgf8a, fgf8b, MGC79739, Xfgf-8, Xfgf8 X. laevis Throughout NF stage 10.5 mesoderm marginal zone otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 10.5 dorsal marginal zone ectoderm gsc.L goosecoid, gsc-a, gsc-b, Xgsc X. laevis Throughout NF stage 10.5 dorsal marginal zone nkx2-5.L AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 X. laevis Throughout NF stage 27 heart en2.L En-2, en2-a, en2-b, eng2, engrailed 2, engrailed homolog 2, engrailed-2, maben, xen2 X. laevis Throughout NF stage 27 midbrain-hindbrain boundary neuroectoderm emx1l.S Xemx1 X. laevis Throughout NF stage 27 telencephalon forebrain dorsal hoxc9-like.L X. laevis Throughout NF stage 27 spinal cord posterior rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Sometime during NF stage 13 to NF stage 21 forebrain otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Throughout NF stage 45 to NF stage 66 forebrain midbrain Image source: Published Larger Image Printer Friendly View

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