Xenbase Image ID: 24781

Fig. 2. XRARα2.2 loss-of-function leads to axial truncations and reduction of HOXB9 expression. (A-D) Microinjection of RAR-MO causes anterior and posterior truncations at highest frequency when expressed in the head region (A) or dorsally (B). (C) Phenotypes are mild to undetectable when the lineage tracer is distributed laterally or ventrally. (D) Phenotypes are rescued by co-injection of XRARα2 mRNA, irrespective of where the lineage tracer is located. (E,F) Neither XBRA (E) nor XWNT8 (F) expression is affected by RAR-MO injection. (G-K) Effects of RAR-MO on the expression of HOXB9. (H-J) The types of phenotypes obtained. (K) HOXB9 expression was restored by co-injecting XRAR mRNA and RAR-MO. Image published in: Shiotsugu J et al. (2004) Copyright © 2004. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue hoxc9-like.L X. laevis Throughout NF stage 18 neural tube posterior neural tube Image source: Published Larger Image Printer Friendly View

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