Xenbase Image ID: 24809

Fig. 4. Ablation of the NP2 domain reduces the otic expression of Pax8 in stage 23/24 embryos. Otx2 (forebrain and eyes) and Krox20 (rhombomeres 3 and 5, arrowheads) (A, B) and Pax8 (C, D) otic expression (arrows) in control embryos at stage 23/24. (E–H) Unilateral ablation of NP2 domain results in reduced Pax8 expression on the manipulated side (G–H; arrows). Sibling embryos after NP2 domain removal (E, F) show reduced Krox20 expression in the hindbrain (residual rhombomere 5 expression can be detected in these embryos; arrowhead) without affecting Krox20 expression domain in the neural crest (nc). Dorsal (A, C, E, G) and lateral (B, D, F, H) views, anterior to left. Image published in: Park BY and Saint-Jeannet JP (2008) Copyright © 2008. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue pax8 pax-8, XPax-8, XPax8 Xenopus Throughout NF stage 23 to NF stage 24 otic region otic placode lateral line placode pronephric mesenchyme otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Sometime during NF stage 23 to NF stage 24 forebrain eye egr2 EGR-2, Krox-20, krox20, XKr20, XKrox-20 Xenopus Sometime during NF stage 23 to NF stage 24 hindbrain neuroectoderm cranial neural crest Image source: Published Larger Image Printer Friendly View

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