Xenbase Image ID: 25101

Figure 6. Elevated FRG1 leads to somite and hypaxial muscle disruptions. A,B: Stage 20 embryos injected with 1 ng of frg1 were analyzed by in situ hybridization with pax3 (A) or myoD (B). C,D: Transverse sections of pax3 and myoD stained embryos are shown in C and D, respectively. The injected sides are denoted by ldquo i rdquo . E-J: Somite disruptions and hypaxial muscle were analyzed in stage 36 embryos injected with 500 pg of frg1 (E,I) and 1 ng of frg1 (G) compared to the uninjected sides F, J, and H, respectively, by myoD (E-H) or pax3 (I,J) in situ hybridization. A graphic summary of somite and hypaxial abnormalities for 500 pg of frg1, 1 ng of frg1, and tracer is shown in K. Image published in: Hanel ML et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue pax3.S cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 35 and 36 muscle hypaxial muscle paraxial mesoderm pax3.S cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 20 paraxial mesoderm myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 20 paraxial mesoderm myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 35 and 36 intersomitic region paraxial mesoderm Image source: Published Larger Image Printer Friendly View

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