Xenbase Image ID: 2555

Fig. 6. The PI3K/Akt pathway is required for eye induction. (A) Injection of δp85 (2 ng) or dnAkt (2 ng) into dorsal animal blastomeres at the 8-cell stage blocked eye formation. (B) δp85 and dnAkt blocked the expression of rx (upper panels) and lhx2 (lower panels) at stage 14. (C) Injection of δp85 or dnAkt into A1 blastomere at the 32-cell stage impaired eye formation on the injected side (left) when embryos reached tadpole stage. Left side was injected. (D) Injection of δp85 (middle panels) or dnAkt (lower panels) into A1 blastomere at the 32-cell stage reduced the expression of rx, but not myoD, otx2, and sox3. n-β-gal was used as a lineage tracer. Image published in: Rorick AM et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue sox3 Sry, Xlsox3, xSox3, Xtsox3 Xenopus Throughout NF stage 14 neuroectoderm otx2 otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 Xenopus Throughout NF stage 14 brain lhx2 lhx2-a, lhx2-b, x-Lhx2, XLhx2 Xenopus Throughout NF stage 14 eye primordium myod1 mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD Xenopus Throughout NF stage 14 muscle rax rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A Xenopus Throughout NF stage 14 eye primordium Image source: Published Larger Image Printer Friendly View

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