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Fig. 3. Overexpression of Nemp1 causes eye defects and reduces expression of eye marker genes at the neurula stage. Embryos were injected with mRNA for Nemp1 or globin as indicated, together with nβ-gal mRNA. (A) Eye-defect phenotypes at the tailbud stage (stages 40–41). Fractions indicate the proportion of the presented phenotype per total number of informative injected embryos. (B) WISH analysis at the neurula stage (stages 13–14). Examined genes are as indicated. Numbers in red, downregulation; numbers in black, normal expression. ant, anterior view (dorsal is upwards); dor, dorsal view (anterior is upwards); arrowhead, injected side. Amounts of injected mRNAs (pg/embryo): nemp1a, 400; globin, 400. Image published in: Mamada H et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 13 to NF stage 14 neuroectoderm eye primordium tbx3.L tbx3-a, tbx3-b, Xltbx3, xtbx3 X. laevis Throughout NF stage 13 to NF stage 14 neuroectoderm eye primordium neural groove cement gland primordium pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 13 to NF stage 14 neuroectoderm eye primordium neural plate chordal neural plate otx2.S otx-2, otx2-a, otx2-b, otxA, Xotx-2, Xotx2 X. laevis Sometime during NF stage 13 to NF stage 14 neuroectoderm eye primordium neural groove anterior neural fold pre-chordal neural plate neural plate forebrain midbrain sox2.L anop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2 X. laevis Throughout NF stage 13 to NF stage 14 chordal neural plate neural plate pre-chordal neural plate neuroectoderm nrp1.L A5 antigen, LOC108718763, neuropilin, neuropilin-1, np-1, npn-1, nrp, nrp-1, pNPG152 X. laevis Sometime during NF stage 13 to NF stage 14 neuroectoderm neural plate anterior neural fold Image source: Published Larger Image Printer Friendly View

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