Xenbase Image ID: 26319

Fig. 4. Rescue of Irx MOs defects. All embryos are at stage 14–16. (A, C, E and G) are anterior and (B, D, F, H) are dorsal views, respectively. Black and red arrowheads point at control and injected sides, respectively. Embryos injected with MT-Irx1-GR (A, C, E, G) or MT-Irx3-GR (B, D, F, H) mRNAs alone (A–D) or with a mix of Irx MOs (E–H). (A–D) In the presence of Dexamethasone, the injected mRNAs caused expansion of Ngnr1 (C) and Gbx2 (D). This is not observed in the absence of the hormone (A, B). (E–H) In embryos co-injected with MT-Irx-GR mRNA and Irx MOs, in the absence of Dex, Ngnr1 (E) and Gbx2 (F) are downregulated. (G, H) This phenotype is rescued in the presence of Dex. Image published in: Rodríguez-Seguel E et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue gbx2.1.S XGBX-2 X. laevis Throughout NF stage 14 to NF stage 16 neural plate rhombomere hindbrain posterior placodal area epidermis neurog2.L atoh4, neurog2-a, neurog2-b, neurogenin 2, neurogenin-2, neurogenin-related-1, neurogenin2, ngn-2, ngn2, ngnr, ngnr 1a, Ngnr-1, Ngnr1, X-ngnr-1, xngn2, Xngnr-1, XNgnr1 X. laevis Throughout NF stage 14 to NF stage 16 neural plate anterior placodal area neuron Image source: Published Larger Image Printer Friendly View

Return to previous page