Xenbase Image ID: 26322

Fig. 7. Arx represses Irx genes. All embryos are dorsal views at stage 14–15. Black and red arrowheads point at the control or injected side, respectively. (A) Double staining of Fezf2 (cyan) and Arx (purple). Both genes share their posterior limits (arrowheads). (B) Double staining of Irx1 (cyan) and Arx (purple) showing the complementary expression domains of these genes. (C) Injection of Fezf1 mRNA expanded Arx posteriorly. (D) In embryos injected with VP16-Znf-GR mRNA Arx expression is shifted anteriorly. (E–F) Overexpression of Arx (E) or Arx-EnR (F) mRNAs downregulated Irx1 (E) and Irx3 (F). (G) Impairment of Arx function with a specific MO expands Irx1 anteriorly. (H) Injection of Arx-VP16 mRNA caused a similar rostral expansion of Irx3. (I) Injection of VP16-Znf-GR mRNA expands anteriorly Irx3 expression. (J) This effect is reverted by overexpressing Arx. Image published in: Rodríguez-Seguel E et al. (2009) Copyright © 2009. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue arx.S arx-a, arx-b, ct121, issx, mrx29, mrx32, mrx33, mrx36, mrx38, mrx43, mrx54, mrx76, mrx87, mrxs1, prt5, xARX X. laevis Throughout NF stage 14 to NF stage 15 diencephalon anterior neural fold irx1.L iro, irx1-a, irx1-b, Xiro, Xiro1 X. laevis Throughout NF stage 14 to NF stage 15 neural plate diencephalon fezf2.L X. laevis Throughout NF stage 14 to NF stage 15 anterior neural fold irx3.L irx3b, MGC131103, xiro-3, xiro3 X. laevis Throughout NF stage 14 to NF stage 15 neural plate diencephalon Image source: Published Larger Image Printer Friendly View

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