Xenbase Image ID: 40739

Fig. 3. Notch signalling regulates pronephric wnt4 expression. (A-D) X. laevis embryos were injected as previously described, with mRNA co-injected with beta-galactosidase mRNA to act as a lineage tracer (red staining on the injected side). Embryos were cultured to stage 28 when wnt4 (A,B), delta1 (C) and serrate1 (D) expression was detected by in situ hybridisation. Mis-activation of Notch signalling by injection of notch-ICD mRNA causes ectopic wnt4 expression (white arrow, A), whereas deltaSTU mRNA inhibits wnt4 expression (B). wnt4 overexpression does not have an effect on delta1 or serrate1 expression levels (B). Expression of both these genes is altered in the anteroposterior register; frequently, expression is more distal (white brackets) and rarely ectopic (white arrow, C). Asterisk denotes injected side. Image published in: Naylor RW and Jones EA (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue wnt4.L wnt-4, Xwnt-4, Xwnt4 X. laevis Throughout NF stage 28 pronephric mesenchyme dll1.L delta-1, Delta-1, delta1, x-delta, X-delta-1, Xdelta-1, Xdelta1, XDelta1 X. laevis Throughout NF stage 28 pronephric mesenchyme jag1.L jagged1, serrate, serrate-1, X-Serrate-1 X. laevis Throughout NF stage 28 pronephric mesenchyme Image source: Published Larger Image Printer Friendly View

Return to previous page