Xenbase Image ID: 40740

Fig. 4. wnt4 acts downstream of the Notch pathway in the pronephros. (A-D) X. laevis embryos were injected as previously described and left to develop to stage 32, when in situ hybridisation detecting expression of nephrin and slc5a2 was performed. (A) Knockdown of wnt4 translation using a MO-inhibited nephrin expression. (B) Co-injection of notch-ICD mRNA and the wnt4 MO also reduces nephrin expression. Co-injection of su(H)DBM mRNA with wnt4 mRNA, causes ectopic glomus formation (white arrow, C) and proximal tubulogenesis (white arrow, D). Asterisk denotes injected side. Image published in: Naylor RW and Jones EA (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue nphs1.S nephrin X. laevis Throughout NF stage 32 glomus slc5a2.L X. laevis Throughout NF stage 32 early proximal tubule late proximal tubule Image source: Published Larger Image Printer Friendly View

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