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Figure 5. Cardiac genes expression at stage 45 by in situ hybridization on section. Transverse and sagittal sections are at the level of the OFT and AV canal, respectively. A,J: Hematoxylin/eosin (H-E) stained sections. Bmp4 (B, K), Msx1 (C, L), and Nkx2.5 (D, M) are expressed in the myocardium. Frzb1 (E, N), Sox8 (F, O), Sox9 (G, P), and Xl-Fli (I, R) are differentially expressed in the mesenchyme of the OFT and AV cushions. Sox10 (H, Q) is detected in the middle portion of the OFT cushion. A, atrium; AV, atrioventricular valve; OFT, outflow tract valve; V, ventricle. Scale bar = 50 mu m. Image published in: Lee YH and Saint-Jeannet JP (2009) Copyright © 2009. Image reproduced with permission of the Publisher, John Wiley & Sons. Gene Synonyms Species Stage(s) Tissue sox10.L X. laevis Throughout NF stage 45 heart sox8.L X. laevis Throughout NF stage 45 heart mesenchyme frzb.S fiz, fre, frp-3, Frzb-1, frzb-pen, frzb1, fzrb, os1, sfrp3, srfp3, xfrzb X. laevis Throughout NF stage 45 heart mesenchyme bmp4.L bmp-4, bmp2b, bmp2b1, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme X. laevis Throughout NF stage 45 heart myocardium nkx2-5.L AR2, csx, Nkx-2.5, nkx-2.5, nkx2-5-a, nkx2-5-b, nkx2.5, tinman, XNkx-2.5, XNkx2-5 X. laevis Throughout NF stage 45 heart myocardium msx1.L hox-7, hox7, msx-1, msx1-a, msx1-b, Xhox-7.1, Xmsx-1, xmsx1 X. laevis Throughout NF stage 45 heart myocardium sox9.S cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 X. laevis Throughout NF stage 45 heart mesenchyme fli1.S fli, fli-1, fli1-a, Xfli, Xfli-1, Xfli1 X. laevis Throughout NF stage 45 heart mesenchyme Image source: Published Larger Image Printer Friendly View

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