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Fig. 3. Mutation of Frizzled4 or coreceptors Lrp5 and Lrp6 prevents normal repair and regeneration of the kidney following ischemia reperfusion injury. (A and B) Lacz staining in d5 post-IRI kidney showing restriction of Fzd4 expression to epithelial tubules and (C) low- (top left) and high-power views (split color panels) showing Fzd4 receptor expression is not present in F4/80+ macrophages in postinjury kidneys. (D–G) PAS-stained sections of normal (D and F) and d5 post-IRI kidneys (E and G) showing persistence of epithelial injury in mice lacking Fzd4 (Fzd4LacZ/LacZ). (H–L) Quantification of inflammation, injury, and repair parameters 5d post-kidney-IRI injury in Fzd4LacZ/LacZ or littermate control mice. (M–R) PAS-stained sections of kidneys. (S and T) Quantification of inflammation, injury, and repair parameters in WT or Lrp5+/lacz; Lrp6+/lacz kidneys. P < 0.05. n = 5 or 6/group. (Scale bars, 50 μm.) Asterisks, regenerating tubules; arrowheads, injured flattened epithelia; nec, necrotic debris. Image published in: Lin SL et al. (2010) Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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