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Xenbase Image ID: 41581

Fig. 3. Bicc1 regulates Pkd2. (A-C) qPCR analysis for mouse Pkd1, Pkd2 and Pkhd1 mRNA levels in Bicc1+/+ (dark gray) and Bicc1−/− (light gray) littermates. The averages and s.d. from six kidney pairs at E15.5 and four pairs at E18.5 are shown (*, P<0.05, Student's t-test). (D) Western blot analysis comparing Pkd2 protein levels in E15.5 kidneys from two Bicc1 mouse litters (#55 and #65) of the indicated genotypes using the Pkd2-specific antibody from Santa Cruz. Actin served as a loading control. (E) Quantification of multiple Pkd2 western blot analyses comparing several mouse litters at E15.5 and normalized to actin. Average values and s.d. are indicated (*, P<0.05, Student's t-test). (F) Whole-mount in situ hybridization for Pkd2 mRNA on uninjected and xBicC-MO1+2-injected Xenopus embryos at stage 39.

Image published in: Tran U et al. (2010)

Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

pkd1l2.LX.laevisThroughout NF stage 39pronephric kidney

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