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Fig. 2. FMR1 interferes with late eye and NC cell development. A. Injection of FMR1 and Control MO had no effect on the expression of neural marker genes at stages 13 and 17. B. FMR1 deficient embryos showed a reduced expression of eye marker genes Rx1 and Pax6 on the injected side (arrows) at stage 23. A quantitative representation is given. C. Inhibition of FMR1 resulted in defects in NC cell migration at stage 20 (FoxD3 expression, arrow) and stage 23 (expression of Krox20 and Twist, arrows). The red brackets highlight the difference of migrating Krox20-positive NC cells between uninjected and FMR1 MO injected sides. A quantitative presentation is shown. n = number of independent experiments; N = number of analyzed embryos. Image published in: Gessert S et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 13 neural crest eye primordium anterior neural fold neuroectoderm sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 13 neural crest eye primordium neural plate anterior neural fold neuroectoderm foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 17 neural crest neural plate neuroectoderm snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 17 neural crest neural plate neuroectoderm pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 23 neural crest eye primordium olfactory placode neuroectoderm egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 23 brain neural crest hindbrain neuroectoderm rhombomere R3 rhombomere R5 twist1.S twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 23 neural crest cranial neural crest mandibular crest hyoid crest branchial crest rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 13 eye primordium anterior neural fold neuroectoderm rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 23 eye primordium foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 23 brain neural crest midbrain hindbrain neuroectoderm Image source: Published Larger Image Printer Friendly View

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