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Fig. 4. Dicer function on a molecular level. A. The injection of 20 ng Dicer MO1 had no effect on Rx1, Pax6 and Sox3 at stage 13 as well as FoxD3 and Slug at stage 17. B. At stage 23, loss of Dicer function by injecting Dicer MO1 and MO2 led to the reduction of eye marker gene expression (black arrows). Control MO injected embryos showed a normal expression pattern. A quantitative presentation is given. C. The migration of NC cells was disturbed upon Dicer MO1 and MO2 injection (black arrows). FoxD3 at stage 20 and Krox20 and Twist at stage 23 were reduced upon loss of Dicer function (black arrows). Control MO injected embryos served as control. A quantitative presentation is given. n = number of independent experiments; N = number of analyzed embryos. Image published in: Gessert S et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 13 eye primordium anterior neural fold pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 13 eye primordium anterior neural fold neural plate neuroectoderm sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 13 neuroectoderm eye primordium anterior neural fold neural plate foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 17 neural crest neuroectoderm neural plate snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 17 neural crest neural plate neuroectoderm pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 23 brain eye primordium olfactory placode neuroectoderm rax.S rax-a, rax-b, rax1, rx, rx-1, rx1, rx1a, Rx2A, Xrax, Xrx1, Xrx1A X. laevis Throughout NF stage 23 eye primordium neuroectoderm foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 23 cranial neural crest brain hindbrain midbrain neuroectoderm egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 23 brain neural crest hindbrain neuroectoderm rhombomere R3 rhombomere R5 twist1.S twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 23 neural crest neuroectoderm cranial neural crest mandibular crest hyoid crest branchial crest Image source: Published Larger Image Printer Friendly View

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