Xenbase Image ID: 42052

Fig. 1. Shroom3 is essential for morphogenesis of the developing Xenopus gut. (A) The expression pattern of Shroom3 in a normal stage 43 dissected gut. Shroom3 is robustly expressed in the foregut (arrow). (B,B′) Normal gut looping in a control stage 46 embryo injected with mRNA encoding GFP only (green in B′). (C,C′) Gut looping is disrupted following dominant-negative (DN)-Shroom3 expression (as marked by GFP, green in C′). (D,E) Control gut (D) and DN-Shroom3-injected (E) gut epithelium. GFP-positive gut epithelial cells display a high-columnar morphology in controls, whereas cells expressing GFP and DN-Shroom3 display more rounded shapes. Image published in: Chung MI et al. (2010) Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue shroom3.L apxl3, shrm, shroom, shroom-like, xshroom3 X. laevis Throughout NF stage 43 foregut hindgut gut epithelium Image source: Published Larger Image Printer Friendly View

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