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Fig. 2. Inhibition of ErbB signaling did not interfere with mesodermal induction in early frog embryos. (A) Expression of the mesodermal marker Brachyury (Xbra), the dorsal mesodermal marker Chordin and the head mesodermal marker Goosecoid was not blocked by loss of ErbB signaling in frog gastrulae. (B) At neurula stages, transcription of the notochord markers Xbra and chordin as well as the neural marker Sox3 was not impaired. The pattern of dorsal gene expression was wider and shorter in ErbB-inhibited embryos compared with that in control embryos. Image published in: Nie S and Chang C (2007) Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 10.5 marginal zone mesoderm tbxt.S bra, brachyury, ntl, t, t-a, t-b, X-bra, Xbra, Xbrachyury X. laevis Throughout NF stage 19 to NF stage 21 posterior axial mesoderm notochord chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 11 to NF stage 11.5 dorsal marginal zone mesoderm chrd.S chd, chordin, chrd.1, LOC108716939, X-chordin X. laevis Throughout NF stage 19 to NF stage 21 axial mesoderm notochord gsc.L goosecoid, gsc-a, gsc-b, Xgsc X. laevis Throughout NF stage 12 to NF stage 12.5 mesoderm head mesoderm sox3.S Sry, Xlsox3, xSox3, Xtsox3 X. laevis Throughout NF stage 19 to NF stage 21 anterior neural fold neural plate Image source: Published Larger Image Printer Friendly View

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