XB-IMG-44836
Xenbase Image ID: 44836
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Fig. 2. XTcf-4 expression is regulated by Wnt/β-Catenin signaling. (A) Xwnt-2b and Xwnt-8, but not Xwnt-5A or Xwnt-11, restore the expression of tcf-4 in Wnt-2b-depleted embryos. Ten picomoles of Wnt-2b morpholino were coinjected with 100 pg of myc-tagged EGFP mRNA and 100 pg cDNA encoding for the indicated Xwnts. At late neurula stages, embryos were sorted by the fluorescence signal of the coinjected EGFP for the injected side. At stage 30, embryos were fixed and stained by in situ hybridization for the expression of tcf-4. Arrowheads mark the reduced tcf-4 expression at the injected side. (B) In situ hybridizations as shown in A were evaluated for tcf-4 expression at the injected side. Given is the percentage of not reduced (wild-type) tcf-4 expression compared to the control side. n indicates the number of analyzed embryos. Image published in: Kunz M et al. (2004) Copyright © 2004. Image reproduced with permission of the Publisher, Elsevier B. V.
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