Xenbase Image ID: 45197

Fig. 4. wt1 and foxc2 are key regulators of the podocyte gene regulatory network. (A) Wire diagram combining the data for the individual knockdowns of the six podocyte transcription factors, showing all the connections. Note that none of the interactions is necessarily direct and might involve intermediary players. (B-G) Whole-mount in situ hybridization for kirrel mRNA expression in uninjected control embryos (B) and Xenopus embryos injected radially with wt1-MO1+2 alone (C) and in the presence of tcf21-MO (D), mafb-MO (E), foxc2-MO (F) or lmx1b-MO (G). (H,H′) kirrel expression in a Xenopus embryo injected unilaterally with wt1-MO1+2 and hey1-MO showing the uninjected (H) or injected (H′) side. Image published in: White JT et al. (2010) Copyright © 2010. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue kirrel1.L kirrel, LOC108699399, LOC108700606, neph1, nephrin-like, nphs1l X. laevis Throughout NF stage 35 and 36 glomus podocyte pronephric kidney Image source: Published Larger Image Printer Friendly View

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