Xenbase Image ID: 45319

Fig. 6. Early requirement of Gbx2 for NC induction. (A-F) In situ hybridization for Gbx2, Pax3 and Msx1 at the indicated stages. Note that only Gbx2 is observed at stage 11. (G-J) Gbx2 MO was injected at the eight-cell stage and the expression of Pax3 and Msx1 was analysed at the indicated stages. Asterisks indicate the injected side (visualized in the inset). Note almost complete inhibition of Pax3 and Msx1 at stage 11.5 (43% of total and 31% of partial inhibition; n=83), and partial inhibition at stage 14 (70% of partial inhibition; n=110). (K) Percentage of embryos with defects in Snail2 expression after activation of GbxEnR-GR with dexamethasone at the indicated stages (s). Image published in: Li B et al. (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue gbx2.2 XGBX-2 Xenopus Sometime during NF stage 11 to NF stage 11.5 neuroectoderm pax3 cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 Xenopus Throughout NF stage 11.5 neuroectoderm msx1 hox-7, hox7, msx-1, msx1-a, msx1-b, Xhox-7.1, Xmsx-1, xmsx1 Xenopus Throughout NF stage 11.5 neuroectoderm Image source: Published Larger Image Printer Friendly View

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