Xenbase Image ID: 46457

Fig. 2. Inhibition of Wnt or Fgf signaling pathway blocks Sox9 expression in the otic placode/vesicle. (A) Sox9 expression is lost in the otic placode (upper panels, stage 17) of embryos injected with 1ng of GSK3β mRNA (arrows, injected side). Sox9 expression is reduced in the otic vesicle (lower panels, stage 23) of embryos injected with 1 ng of dominant-negative FgfR (XFD) mRNA (arrows, injected side). For comparison, normal expression of Sox9 is shown on the uninjected side of these embryos (arrows, uninjected side) at stage 17 and stage 23. As Fgf signaling is also required for development of posterior structures, XFD/FgfR-injected present a characteristic open blastopore (lower panels). All panels are lateral views, anterior towards the right (left panels) or anterior towards the left (right panels). (B) Transverse section through an embryo injected with GSK3β (upper panel) or XFD/FgfR (lower panel) mRNA. In both cases the embryos present a reduced otic vesicle on the injected side (left side, arrows). br, brain; no, notochord; ov, otic vesicle. Image published in: Saint-Germain N et al. (2004) Copyright © 2004. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue sox9 cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 Xenopus Throughout NF stage 17 sensorial layer of neurectoderm sox9 cmd1, cmpd1, sox-9, sox9-a, sox9-b, sra1 Xenopus Throughout NF stage 23 otic placode Image source: Published Larger Image Printer Friendly View

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