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XB-IMG-48480

Xenbase Image ID: 48480


Fig. 6. Increasing Rx1 levels at stage 12 represses stem cell, neural identity and differentiation marker genes. (A) pax6 expression domain in the optic vesicle is smaller (arrow), and repressed in β-Gal labeled cells (inset, arrowheads). (B) In a small percentage of stage 38 embryos, pax6 expression is repressed in β-Gal labeled cells (arrowheads). (C) six3 expression domain in the optic vesicle is smaller (arrow). (D) In most stage 38 embryos, six3 expression is normal in β-Gal labeled cells (arrowheads). (E) notch1 expression domain in the optic vesicle is smaller (arrow), and repressed in β-Gal labeled cells (inset, arrowheads). (F) By stage 38 there is no repression surrounding β-Gal-labeled nuclei (arrowheads). (G) sox2 expression domain in the optic vesicle is smaller (arrow). (H) By stage 38 there is no repression surrounding β-Gal-labeled nuclei (arrowheads). (I) ngn1 expression in the optic cup (arrow) is fainter (cf. Fig. 5L) and repressed in β-Gal labeled cells (inset, arrowheads). (J) At stage 38, ngn1 expression continues to be repressed surrounding β-Gal-labeled nuclei (arrowheads). (K) p27 expression in the optic cup (arrow) is fainter (cf. Fig. 5N). (L) At stage 38, p27 expression continues to be repressed surrounding β-Gal-labeled nuclei (arrowheads) in some embryos. (M) neuroD expression in the optic cup (arrow) is greatly reduced (cf. Fig. 5P). (N) At stage 38, neuroD continues to be repressed surrounding β-Gal labeled nuclei (arrowheads). (O) Xath5 expression in the optic cup (arrow) is greatly reduced (cf. Fig. 5R). (P) At stage 38, Xath5 expression continues to be repressed surrounding β-Gal-labeled nuclei (arrowheads) in some embryos. Data for stage 16 activation are similar. Dashed lines indicate the outline of the retinas in the sectioned material. For whole mounts, bars = 100 μm; for sections bars = 20 μm.

Image published in: Zaghloul NA and Moody SA (2007)

Copyright © 2007. Image reproduced with permission of the Publisher, Elsevier B. V.

GeneSynonymsSpeciesStage(s)Tissue
pax6.Lan2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6X. laevisThroughout NF stage 20optic vesicle
eye primordium
retina
lens placode
neural tube
six3.Lhpe2, six3-a, six3-b, XSix3, xsix3.1, xsix3.2X. laevisThroughout NF stage 20retina
eye primordium
notch1.Snotch, notch-1, x-notch-1, xnotch, xnotch1, xotchX. laevisThroughout NF stage 20retina
diencephalon
neural tube
sox2.Lanop3, LOC108718087, mcops3, Sox-2, XLSOX-2, Xsox-2, XSox2X. laevisThroughout NF stage 20retina
eye primordium
diencephalon
neural tube

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