XB-IMG-48518
Xenbase Image ID: 48518
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Fig. 1. dkk1 but not frzb induces complete secondary heads. Coinjections of tBR mRNAs with dkk1 (A) or frzb (B) into ventral blastomeres of four-cell embryos results in the development of secondary heads with two eyes or one eye, respectively. Embryos shown are 4 days postfertilisation (pf). (C-G) dkk1 rescues the cyclopic phenotype elicited by anti15 Ab, while frzb and bhh are unable to rescue cyclopia. Embryos are day 6 pf, shown from the dorsal side, anterior up. (C) Uninjected control embryo. (D) Embryo injected with anti15 Ab into the blastocoel. (E) Embryo injected radially with dkk1 mRNA and anti15 Ab. (F) Embryo injected radially with frzb mRNA and anti15 Ab. (G) Embryo injected radially with bhh mRNA and anti15 Ab. (H) Embryo injected radially with bhh mRNA. (I) Uninjected control embryo. Image published in: Kazanskaya O et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View |