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Fig. 7. dkk1 rescues embryos posteriorized by bFGF, BMP4, XSmad1 and Wnt3A, but not by RA. Where indicated, embryos were injected radially at the four-cell stage with dkk1 or frzb mRNA. (A,B) Embryos treated from stages 8-13 with 10−7M retinoic acid (RA). (D-F) Embryos were injected radially at the four- cell stage with BMP4 or (G-I) XSmad1 mRNA. (J-L) Embryos were injected radially at the four-cell stage with dkk1 or frzb mRNA and at the blastula stage with bFGF protein into the blastocoel. (M-O) Embryos were injected animally at the four-cell stage with mWnt3A plasmid DNA. (C) Uninjected control. Image published in: Kazanskaya O et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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