Xenbase Image ID: 49381

Figure 5. FoxC1 target genes and apoptosis at the early tailbud stage (stage 20) (A–D). Real-time RT-PCR analysis of the equatorial zones (equators) and vegetal masses (bases) shown in Figure 3 (F and I) for E and EP cadherin and occludin (A); Ephrin B1 and 3, EphB2 and 3, and Ephrin A4 (B); FGF8, MyoD, and SCL (C); and Sox17 and GATA5 (D). Expression was normalized to ODC. E–G: Oocyte-derived, FoxC1-depleted embryos were hemisected in the sagittal plane and subject to TUNEL staining at stage 20. FoxC1-depleted embryos exhibited more cell apoptosis particularly in the mesoderm (F) compared to controls (E), and this effect was rescued by reintroducing MO-R FoxC1 mRNA (G). Image published in: Cha JY et al. (2007) Copyright © 2007. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View

Return to previous page