Xenbase Image ID: 49514

Figure 2. Admp Expression Is Triggered by Low BMP Signaling, and Admp MO Dorsalizes the Embryo. (A) The Xenopus ventral and dorsal centers. (B) Admp is expressed dorsally (stage 12). (C) Chordin protein injection in the blastula cavity (5 ng) leads to upregulation of Admp expression. (D) Admp MO targeting both Xenopus laevis Admp pseudoalleles. (E) Xenopus Admp translation is specifically inhibited by Admp MO but not by control MO of random sequence. (F) ADMP causes phosphorylation of endogenous Smad1 in Xenopus embryos, which is blocked by Chordin protein injection.(G and H) Admp MO-injected embryos (12 ng total) are dorsalized.(I) zAdmp mRNA (75 pg total) ventralizes the Xenopus embryo.(J) Admp MO rescued by zAdmp mRNA. Image published in: Reversade B and De Robertis EM (2005) Copyright © 2005. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue admp.S X. laevis Throughout NF stage 12 axial mesoderm en2.L En-2, en2-a, en2-b, eng2, engrailed 2, engrailed homolog 2, engrailed-2, maben, xen2 X. laevis Throughout NF stage 20 presumptive midbrain-hindbrain boundary six3.L hpe2, six3-a, six3-b, XSix3, xsix3.1, xsix3.2 X. laevis Throughout NF stage 20 optic field eye primordium szl.L frzb3, secreted frizzled, sizzled, xszl X. laevis Throughout NF stage 20 ventral myod1.S mf25, MyoD, myod1-a, myod1-b, myogenic factor 3, XMyoD, XtmyoD X. laevis Throughout NF stage 12 presomitic mesoderm Image source: Published Larger Image Printer Friendly View

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