Xenbase Image ID: 49606

Fig. S1. Targeting su(H)DBM mRNA to the pronephros causes the same pronephric phenotypes as deltaSTU overexpression. (A-D) X. laevis embryos were injected into a V2 blastomere with su(H)DBM mRNA, which encodes a dominant-negative form of Su(H). Embryos were left to develop to various stages of development, when in situ hybridisation detecting expression of Na+K+ATPase, slc5a2, nephrin and odf3 was performed. su(H)DBM overexpression inhibited expression of the proximal domain of Na+K+ATPase (A) and completely inhibited expression of slc5a2 (B), nephrin (C) and odf3 (D). These results are identical to the effect deltaSTU overexpression has on pronephrogenesis. Asterisk denotes injected side. Image published in: Naylor RW and Jones EA (2009) Copyright © 2009. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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